井上英之研究室 （社会起業）

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Stanford University's Justin Sonnenburg and colleagues used 16S ribosomal RNA sequencing as part of their effort to look at ways in which the gut microbial community composition and glycan content in host intestinal mucus shift in relation to diet. Through a series of humanized mouse experiments, the team found that mutant animals missing a mucus-related gene had different gut microbes and intestinal mucus composition when fed diets high in glucose and lacking plant polysaccharides than when fed a typical diet with plenty of polysaccharides. "Together, these data demonstrate the differences in host genotype that affect the carbohydrate landscape of the distal gut interact with diet to alter the composition and function of resident microbes in a diet-dependent manner," they write.

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